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Srinivas, B.
- Darivatization and Pharmacological Evaluation of New 4 Substituted 5 -phenyl-3-mercapto-1,2,4-Triazoles
Authors
1 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP, IN
2 Talla Padmavathi College of Pharmacy, ours, Karimabad, Warangal, AP, IN
3 Procadence Institute of Pharmaceutical Sciences. Gajwel, Medak,. A.P, IN
4 Jyothishmathi Institute of Pharmaceutical Science, Ramakrishna colony, Karimnagar, AP
Source
Asian Journal of Research in Chemistry, Vol 6, No 8 (2013), Pagination: 731-734Abstract
An efficient method for synthesis of 4 substituted 5 -phenyl - 3- mercapto -1, 2, 4 -triazole, by the mode of ring cleavage of oxadiazoles, nucleophiles are readily attack 5-phenyl 1,3,4- oxadiazole-2 - thiols and they are cleaved by acids and basis, in a reaction, which is the reverse of the ring closure, many nucleophilic ring cleavage reaction are followed by recyclization to give different heterocyclics, we were sysnthsized 5 different compounds and characterized its physical data, spectral analysis by IR and these compounds screened for possible CNS activity.Keywords
Triazoles, Oxadiazole, Grass Behavior Study, Locomotor Activity
References
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- Platelet Count Estimation by Peripheral Smear Method and Automated Method in Pregnant Women
Authors
1 CKM Hospital, Warangal-506002, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 139-141Abstract
Background
Platelet count is an important investigation done in pregnant women. Platelet count is routinely done by automated method. The automated cell counters are not available at all hospital setups especially in rural side. Platelets can also be estimated from the peripheral smears, which can be easily done at any set up.
Aims and Objective: This study was conducted to compare the platelet estimation by peripheral smear method and automated method.
Materials and Methods: Platelet estimation was done in 50 normal pregnant women by stained peripheral smear and automated method. Platelet counts were expressed in Mean ± SD. Statistical analysis was done by student's t test.
Results: Platelet counts were 2.76 ± 0.71 and 2.64 ± 0.73 lacs/mm3 by peripheral smear and automated method respectively with p value 0.4.
Conclusion: There was no significant difference between two methods, hence it proves that the two methods are same.
Keywords
Platelet Count, Peripheral Smear, Automatic Analyser.- Stable and pH-Responsive Core–Shell Nanoparticles Based on HEC and PMAA Networks via Template Copolymerization
Authors
1 Dr. Reddys Laboratories, Bachupally, Hyderabad, A.P., IN
2 Mother Teresa College of Pharmaceutical Sciences, NFC Nagar, Ghatkesar, IN
3 Anurag Pharmacy College, Kodad, AP, IN
4 RS I Laboratories, Hyderabad, AP, IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 108-115Abstract
Taking advantage of the specific hydrogen bonding interactions, stable and pH-responsive core-shell nanoparticles based on hydroxyethyl cellulose (HEC) and polymethacrylic acid (PMAA) networks, with a (Dh ) size ranging from 190 to 250 nm, can be efficiently prepared via facile one-step co-polymerization of methacrylic acid (MAA) and N,N'- methylenebisacrylamide (MBA) on HEC template in water. Using dynamic light scattering, electrophoretic light scattering, fluorescence spectrometry, thermo-gravimetric analysis, TEM, and AFM observations, the influence of crosslinker MBA as well as the reaction parameters were studied. The results show that after the introduction of crosslinker MBA, the nanoparticles became less compact; their size exhibited a smaller pH sensitivity, and their stability against pH value was improved greatly. Furthermore, the size, structure, and pH response of the nanoparticles can be adjusted via varying the reaction parameters: nanoparticles of smaller size, more compact structure, and higher swelling capacity were produced as pH value of the reaction medium increased or the HEC/MAA ratio decreased; while nanoparticles of smaller size, less compact structure and smaller swelling capacity were produced as the total feeding concentration increased.
Keywords
Core, Shell Nanoparticles, Synthesis, Template Polymerization, pH Sensitivity, Crosslinking.- Optimum Replacement Period for Motor Vehicle Considering Macroeconomic Parameters
Authors
1 JDA Software India Ltd., Madhapur, Hyderabad-500032, AP State, IN
2 Mechanical Engineering Department, M.V.S.R. Engineering College, Nadergul, Hyderabad-501510, AP State, IN
3 JNTUA, Anantapur, AP State, IN
Source
International Journal of Engineering Research, Vol 2, No 4 (2013), Pagination: 290-293Abstract
The present work is a contribution of mathematical and operations research models that help in arriving at the best replacement strategies to determine an age of motor vehicle at which the replacement is most economical. Parameters like depreciation, money value, forecasted inflation, nominal interest rate and real interest rate are taken into consideration in model development and for various situations, the replacement period to motor vehicle is suggested.Keywords
Replacement, Inflation, Forecasting, Interest Rates, and Money Value.Full Text
- Fluoride Distribution in the Groundwater of Gangadhara Area, Karimnagar District, Telangana, India
Authors
1 Department of Applied Geochemistry, Osmania University, Hyderabad-500007, Telangana, IN
2 Department of Chemistry, MVSR College of Engineering, Nadergul, Hyderabad-501510, IN
Source
International Journal of Earth Sciences and Engineering, Vol 9, No 2 (2016), Pagination: 568-573Abstract
Hydrogeochemical investigations have been carried out in parts of Karimnagar district of Telangana to study the distribution of fluoride in groundwater of Gangadhara area. Eighty five groundwater samples were analyzed in January, 2013 (post-monsoon) and also in June, 2013 (pre-monsoon) for pH, Ec and Fluoride. It is observed that the groundwater in both the seasons is alkaline in nature. 39% of groundwater in post- monsoon and 23.52% of groundwater in pre-monsoon has higher concentration of Electrical conductivity than the prescribed limit. The higher values indicate that ionic concentrations are more in the groundwater. Nearly 65% of groundwater has more than the permissible limits of fluoride prescribed for drinking purpose in both post-monsoon and pre-monsoon seasons in the study area.Keywords
Pre-Monsoon, Post-Mnsoon, Groundwater, Granitic Terrain, Fluoride Distribution, Electrical Conductivity, Karimnagar District, Telangana.Full Text